MOTS-c 40mg 3ml Research Peptide UK

MOTS-c 40mg: High-Concentration Mitochondrial Peptide

Bulk Formulation Summary

The peptide MOTS-c comes in 40 MG per laboratory vial and is 98% pure verified through mass spectrometry and HPLC. It is physically present in freeze-dried powder complexes.

Biochemical Mechanics & Research Scope

MOTS-c is a unique peptide when it comes to structure, and it is entirely encoded in the mitochondrial DNA. Contrary to the traditional nuclear-encoded signaling proteins, this is a mitochondrial peptide that translocates to the cell nucleus to modulate genetic expression when there is a metabolic shift in cellular models.

The 40mg vial is a high-capacity peptide, and it is optimized for extensive assays in the laboratory. It is also used in comparative in-vitro signaling studies that specifically focus on

• Cellular Homeostasis: analyzing the communication loop between nuclear transcription and mitochondrial activity.
• Metabolic Stress Responses: finding how the cell cultures adapt to energy changes or nutrient deprivation at a molecular level. 
• Enzymatic Pathways: examining the structural interaction of peptides with cellular enzymes including the AMPK signaling network, thoroughly.

Standard Operating Procedure: Storage & Care

If you want to preserve the structural integrity of any peptide there are certain laboratory controls that you will have to implement that include

• Storing the vial at -20°C and keeping it in a frozen and dry state so it remains stable for up to two years.
• If you are going to introduce the sample to a testing framework within 21 days, you can hold it temporarily at 4°C
• Once you have mixed this liquid with any laboratory solvent, you should store the solution at 4°C and complete the analytical evaluation within 20 days
• Lastly, you should always keep it protected from direct light because this can affect the structural integrity of the peptide.

This listing features a pre-mixed, ready-to-use 3ml vial containing 40mg of research-grade MOTS-c — providing consistent concentration for precise laboratory protocols without the requirement for manual reconstitution.

Key Research Areas MOTS-c is studied extensively in preclinical and in-vitro settings for its roles in:

• AMPK pathway activation — MOTS-c directly activates AMP-activated protein kinase (AMPK), a master energy sensor involved in energy homeostasis, mitochondrial biogenesis, and metabolic regulation
• Glucose metabolism & insulin sensitivity — preclinical studies demonstrate improvements in insulin-stimulated glucose uptake in skeletal muscle and reduction of intramuscular fat accumulation, relevant to insulin resistance and type 2 diabetes models
• Exercise mimetic effects — MOTS-c activates many of the same molecular pathways induced by physical activity, including AMPK and PGC-1α, independent of exercise itself
• Mitochondrial bioenergetics — modulation of oxidative phosphorylation efficiency and reduction of mitochondrial reactive oxygen species (ROS)
• Age-related metabolic decline & sarcopenia — endogenous MOTS-c levels correlate inversely with muscle loss in ageing models; supplementation shown to restore skeletal muscle metabolic flexibility in aged mice
• Anti-inflammatory & antinociceptive pathways — activation of AMPK pathway and inhibition of MAP kinase/c-Fos signalling, leading to reduced pro-inflammatory cytokine expression in preclinical models
• Cardiovascular research — emerging investigation into MOTS-c's role in cardiac metabolism and cardiovascular resilience under metabolic stress
• Neuroprotective potential — early-stage research into mitochondrial dysfunction in neurodegenerative disease models, given the established link between metabolic impairment and neurodegeneration
• Longevity & lifespan studies — preclinical models suggest MOTS-c supplementation may extend lifespan and improve healthspan under metabolic stress conditions

Product Specifications

• CAS Number: 1627580-64-6
• Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
• Other Names: Mitochondrial open reading frame of the 12S RNA-c, MT-RNR1, Humanin-like 13 (HN13)
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: 2,174.64 g/mol
• Amino Acids: 16
• Quantity: 40mg per vial
• Volume: 3ml (pre-mixed)
• Purity: ≥99% (HPLC verified)
• Form: Pre-mixed solution
• Appearance: Clear to off-white solution
• Solubility: Water soluble
• Storage: Refrigerate at 2–8°C once mixed. Do not freeze reconstituted solution. Protect from light. Avoid repeated freeze-thaw cycles. Lyophilised (unmixed) stable at −20°C for 2+ years.
• Shelf life (pre-mixed): Use within 21–28 days. Inspect before each use — discard if discoloured or particulate present.
• Dispatch: Fast UK dispatch. Orders placed before 2 pm are dispatched on the is same working day.

Concentration At 40mg in 3ml: concentration = 13.33mg/ml (13,333mcg/ml)

COA Available: Every batch independently third-party tested. Certificate of Analysis available on our Lab Reports page before ordering.

All products sold by Ultra Peptides are strictly for laboratory and in-vitro research purposes only. Not intended for human or veterinary use. Not approved by the MHRA for any medical, therapeutic, or clinical application. By purchasing this product, you confirm your intended use is for legitimate scientific research conducted in a controlled laboratory setting.