MOTS-c 40mg 3ml Research Peptide UK

For research use only. Not for human consumption.

MOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) — 40mg | Pre-Mixed 3ml Vial | ≥99% Purity | COA Verified | UK Dispatch

MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) first described in 2015, encoded within the 12S rRNA gene of the mitochondrial genome — a region not previously known to produce bioactive peptides. It is one of only a small number of known peptides encoded by mitochondrial DNA rather than nuclear DNA, placing it in a unique and rapidly expanding class of mitochondrial-derived signalling peptides. MOTS-c levels in humans decline progressively with age and in response to metabolic stress, making it a significant subject of longevity, metabolic, and exercise biology research.

This listing features a pre-mixed, ready-to-use 3ml vial containing 40mg of research-grade MOTS-c — providing consistent concentration for precise laboratory protocols without the requirement for manual reconstitution.

Key Research Areas MOTS-c is studied extensively in preclinical and in-vitro settings for its roles in:

• AMPK pathway activation — MOTS-c directly activates AMP-activated protein kinase (AMPK), a master energy sensor involved in energy homeostasis, mitochondrial biogenesis, and metabolic regulation
• Glucose metabolism & insulin sensitivity — preclinical studies demonstrate improvements in insulin-stimulated glucose uptake in skeletal muscle and reduction of intramuscular fat accumulation, relevant to insulin resistance and type 2 diabetes models
• Exercise mimetic effects — MOTS-c activates many of the same molecular pathways induced by physical activity, including AMPK and PGC-1α, independent of exercise itself
• Mitochondrial bioenergetics — modulation of oxidative phosphorylation efficiency and reduction of mitochondrial reactive oxygen species (ROS)
• Age-related metabolic decline & sarcopenia — endogenous MOTS-c levels correlate inversely with muscle loss in ageing models; supplementation shown to restore skeletal muscle metabolic flexibility in aged mice
• Anti-inflammatory & antinociceptive pathways — activation of AMPK pathway and inhibition of MAP kinase/c-Fos signalling, leading to reduced pro-inflammatory cytokine expression in preclinical models
• Cardiovascular research — emerging investigation into MOTS-c's role in cardiac metabolism and cardiovascular resilience under metabolic stress
• Neuroprotective potential — early-stage research into mitochondrial dysfunction in neurodegenerative disease models, given the established link between metabolic impairment and neurodegeneration
• Longevity & lifespan studies — preclinical models suggest MOTS-c supplementation may extend lifespan and improve healthspan under metabolic stress conditions

Product Specifications

• CAS Number: 1627580-64-6
• Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
• Other Names: Mitochondrial open reading frame of the 12S RNA-c, MT-RNR1, Humanin-like 13 (HN13)
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: 2,174.64 g/mol
• Amino Acids: 16
• Quantity: 40mg per vial
• Volume: 3ml (pre-mixed)
• Purity: ≥99% (HPLC verified)
• Form: Pre-mixed solution
• Appearance: Clear to off-white solution
• Solubility: Water soluble
• Storage: Refrigerate at 2–8°C once mixed. Do not freeze reconstituted solution. Protect from light. Avoid repeated freeze-thaw cycles. Lyophilised (unmixed) stable at −20°C for 2+ years.
• Shelf life (pre-mixed): Use within 21–28 days. Inspect before each use — discard if discoloured or particulate present.
• Dispatch: Fast UK dispatch. Orders placed before 2pm dispatched same working day.

Concentration At 40mg in 3ml: concentration = 13.33mg/ml (13,333mcg/ml)

COA Available: Every batch independently third-party tested. Certificate of Analysis available on our Lab Reports page before ordering.

All products sold by Ultra Peptides are strictly for laboratory and in-vitro research purposes only. Not intended for human or veterinary use. Not approved by the MHRA for any medical, therapeutic, or clinical application. By purchasing this product you confirm your intended use is for legitimate scientific research conducted in a controlled laboratory setting.