{"product_id":"mots-c-40mg-3ml-research-peptide-uk","title":"MOTS-c 40mg 3ml Research Peptide UK","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eFor research use only. Not for human consumption.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) — 40mg | Pre-Mixed 3ml Vial | ≥99% Purity | COA Verified | UK Dispatch\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eMOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) first described in 2015, encoded within the 12S rRNA gene of the mitochondrial genome — a region not previously known to produce bioactive peptides. It is one of only a small number of known peptides encoded by mitochondrial DNA rather than nuclear DNA, placing it in a unique and rapidly expanding class of mitochondrial-derived signalling peptides. MOTS-c levels in humans decline progressively with age and in response to metabolic stress, making it a significant subject of longevity, metabolic, and exercise biology research.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThis listing features a \u003cstrong\u003epre-mixed, ready-to-use 3ml vial\u003c\/strong\u003e containing \u003cstrong\u003e40mg of research-grade MOTS-c\u003c\/strong\u003e — providing consistent concentration for precise laboratory protocols without the requirement for manual reconstitution.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eKey Research Areas\u003c\/strong\u003e MOTS-c is studied extensively in preclinical and in-vitro settings for its roles in:\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eAMPK pathway activation\u003c\/strong\u003e — MOTS-c directly activates AMP-activated protein kinase (AMPK), a master energy sensor involved in energy homeostasis, mitochondrial biogenesis, and metabolic regulation\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eGlucose metabolism \u0026amp; insulin sensitivity\u003c\/strong\u003e — preclinical studies demonstrate improvements in insulin-stimulated glucose uptake in skeletal muscle and reduction of intramuscular fat accumulation, relevant to insulin resistance and type 2 diabetes models\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eExercise mimetic effects\u003c\/strong\u003e — MOTS-c activates many of the same molecular pathways induced by physical activity, including AMPK and PGC-1α, independent of exercise itself\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eMitochondrial bioenergetics\u003c\/strong\u003e — modulation of oxidative phosphorylation efficiency and reduction of mitochondrial reactive oxygen species (ROS)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eAge-related metabolic decline \u0026amp; sarcopenia\u003c\/strong\u003e — endogenous MOTS-c levels correlate inversely with muscle loss in ageing models; supplementation shown to restore skeletal muscle metabolic flexibility in aged mice\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eAnti-inflammatory \u0026amp; antinociceptive pathways\u003c\/strong\u003e — activation of AMPK pathway and inhibition of MAP kinase\/c-Fos signalling, leading to reduced pro-inflammatory cytokine expression in preclinical models\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eCardiovascular research\u003c\/strong\u003e — emerging investigation into MOTS-c's role in cardiac metabolism and cardiovascular resilience under metabolic stress\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eNeuroprotective potential\u003c\/strong\u003e — early-stage research into mitochondrial dysfunction in neurodegenerative disease models, given the established link between metabolic impairment and neurodegeneration\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eLongevity \u0026amp; lifespan studies\u003c\/strong\u003e — preclinical models suggest MOTS-c supplementation may extend lifespan and improve healthspan under metabolic stress conditions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eProduct Specifications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1627580-64-6\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eAmino Acid Sequence:\u003c\/strong\u003e Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eOther Names:\u003c\/strong\u003e Mitochondrial open reading frame of the 12S RNA-c, MT-RNR1, Humanin-like 13 (HN13)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₀₁H₁₅₂N₂₈O₂₂S₂\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 2,174.64 g\/mol\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eAmino Acids:\u003c\/strong\u003e 16\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eQuantity:\u003c\/strong\u003e 40mg per vial\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eVolume:\u003c\/strong\u003e 3ml (pre-mixed)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥99% (HPLC verified)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Pre-mixed solution\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eAppearance:\u003c\/strong\u003e Clear to off-white solution\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Water soluble\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Refrigerate at 2–8°C once mixed. Do not freeze reconstituted solution. Protect from light. Avoid repeated freeze-thaw cycles. Lyophilised (unmixed) stable at −20°C for 2+ years.\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eShelf life (pre-mixed):\u003c\/strong\u003e Use within 21–28 days. Inspect before each use — discard if discoloured or particulate present.\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eDispatch:\u003c\/strong\u003e Fast UK dispatch. Orders placed before 2pm dispatched same working day.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e At 40mg in 3ml: \u003cstrong\u003econcentration = 13.33mg\/ml (13,333mcg\/ml)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCOA Available:\u003c\/strong\u003e Every batch independently third-party tested. Certificate of Analysis available on our Lab Reports page before ordering.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eAll products sold by Ultra Peptides are strictly for laboratory and in-vitro research purposes only. Not intended for human or veterinary use. Not approved by the MHRA for any medical, therapeutic, or clinical application. By purchasing this product you confirm your intended use is for legitimate scientific research conducted in a controlled laboratory setting.\u003c\/em\u003e\u003c\/p\u003e","brand":"Ultra Peptides","offers":[{"title":"Default Title","offer_id":47496611397826,"sku":null,"price":59.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0742\/4481\/7090\/files\/MOTS-c---40mg---3ml.png?v=1776889772","url":"https:\/\/ultrapeptides.co.uk\/products\/mots-c-40mg-3ml-research-peptide-uk","provider":"Ultra Peptides","version":"1.0","type":"link"}